Tehran University of Medical Sciences Journal of Medical Ethics and History of Medicine 2008-0387 16 0 2023 12 02 1321 1321 Gita Shafiee Associated Professor, Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Narges Zargar Balajam Researcher, Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Ramin Heshmat Professor, Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Bagher Larijani Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. 2023 04 16 2023 12 02 As the population ages, the number of older people with various geriatric diseases is increasing.  Sarcopenia is one of the important geriatric diseases with high mortality and morbidity. Some research needs to understand risk factors, diagnosis, and prevention, and develop treatment options with high safety and efficacy for sarcopenic people. To reduce the risks involved with sarcopenic people in clinical research, it is necessary to consider the ethical review of research on this issue. Therefore, this study aimed to guide on the ethical issues of sarcopenia research. https://jmehm.tums.ac.ir/index.php/jmehm/article/view/1321 https://jmehm.tums.ac.ir/index.php/jmehm/article/download/1321/417